Master List of Migraine Research Articles

For those of you interested in learning more about migraine, the gut-brain connection, hormones, supplements, and more!

How to look up an article – you can simply click on the url at the end of the citation (the “doi”) and google it! You can also try googling the article’s title. For best results, use


  • Martami, F., Razeghi Jahromi, S., Togha, M., Ghorbani, Z., Seifishahpar, M., & Saidpour, A. (2018). The serum level of inflammatory markers in chronic and episodic migraine: A case-control study. Neurological Sciences, 39(10), 1741-1749.
  • Togha, M., Razeghi Jahromi, S., Ghorbani, Z., Ghaemi, A., & Rafiee, P. (2019). An investigation of oxidant/antioxidant balance in patients with migraine: A case-control study. BMC Neurology, 19(1).
  • Peng, K., & May, A. (2019). Migraine understood as a sensory threshold disease. Pain, 160(7), 1494-1501.

Migraine and Gut Health

  • Guo, R., Chen, L., Xing, C., & Liu, T. (2019). Pain regulation by gut microbiota: Molecular mechanisms and therapeutic potential. British Journal of Anaesthesia, 123(5), 637-654.
  • Martami, F., Togha, M., Seifishahpar, M., Ghorbani, Z., Ansari, H., Karimi, T., & Jahromi, S. R. (2019). The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial. Cephalalgia, 39(7), 841-853.
  • Tang, Y., Liu, S., Shu, H., Yanagisawa, L., & Tao, F. (2019). Gut microbiota Dysbiosis enhances migraine-like pain via TNFα Upregulation. Molecular Neurobiology, 57(1), 461-468.
  • Arzani, M., Jahromi, S. R., Ghorbani, Z., Vahabizad, F., Martelletti, P., Ghaemi, A., Sacco, S., & Togha, M. (2020). Gut-brain Axis and migraine headache: A comprehensive review. The Journal of Headache and Pain, 21(1).
  • De Roos, N. M., Van Hemert, S., Rovers, J. M., Smits, M. G., & Witteman, B. J. (2017). The effects of a multispecies probiotic on migraine and markers of intestinal permeability–results of a randomized placebo-controlled study. European Journal of Clinical Nutrition, 71(12), 1455-1462.
  • Naghibi, M. M., & Day, R. (2019). The microbiome, the gut–brain axis and migraine. Gastrointestinal Nursing, 17(8), 38-45.

Migraine and IBS

  • Cámara-Lemarroy, C. R., Rodriguez-Gutierrez, R., Monreal-Robles, R., & Marfil-Rivera, A. (2016). Gastrointestinal disorders associated with migraine: A comprehensive review. World Journal of Gastroenterology, 22(36), 8149.
  • Chang, F., & Lu, C. (2013). Irritable bowel syndrome and migraine: Bystanders or partners? Journal of Neurogastroenterology and Motility, 19(3), 301-311.
  • Georgescu, D., Reisz, D., Gurban, C. V., Georgescu, L., Ionita, I., Ancusa, O. E., & Lighezan, D. (2017). Migraine in young females with irritable bowel syndrome: Still a challenge. Neuropsychiatric Disease and Treatment, 14, 21-28.

Migraine and Diet

  • Gazerani, P. (2020). Migraine and diet. Nutrients, 12(6), 1658.
  • Razeghi Jahromi, S., Ghorbani, Z., Martelletti, P., Lampl, C., & Togha, M. (2019). Association of diet and headache. The Journal of Headache and Pain, 20(1).
  • Nowaczewska, M., Wiciński, M., & Kaźmierczak, W. (2020). The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment. Nutrients, 12(8), 2259.
  • Ramsden, C. E., Zamora, D., Faurot, K. R., MacIntosh, B., Horowitz, M., Keyes, G. S., Yuan, Z., Miller, V., Lynch, C., Honvoh, G., Park, J., Levy, R., Domenichiello, A. F., Johnston, A., Majchrzak-Hong, S., Hibbeln, J. R., Barrow, D. A., Loewke, J., Davis, J. M., … Mann, J. D. (2021). Dietary alteration of N-3 and N-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial. BMJ, n1448.

Supplements, Vitamins, Minerals

  • Martins, L. B., Rodrigues, A. M., Rodrigues, D. F., Dos Santos, L. C., Teixeira, A. L., & Ferreira, A. V. (2018). Double-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment. Cephalalgia, 39(1), 68-76.
  • Maghbooli, M., Golipour, F., Moghimi Esfandabadi, A., & Yousefi, M. (2013). Comparison between the efficacy of ginger and Sumatriptan in the ablative treatment of the common migraine. Phytotherapy Research, 28(3), 412-415.
  • Ernst, E., & Pittler, M. H. (2000). Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. British journal of anaesthesia, 84(3), 367–371.
  • Sun-Edelstein, C., & Mauskop, A. (2009). Role of magnesium in the pathogenesis and treatment of migraine. Expert Review of Neurotherapeutics, 9(3), 369-379.
  • Shin, H.-J., Na, H.-S., & Do, S.-H. (2020). Magnesium and Pain. Nutrients, 12(8), 2184.
  • Song, T. J., Chu, M. K., Sohn, J. H., Ahn, H. Y., Lee, S. H., & Cho, S. J. (2018). Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. Journal of clinical neurology (Seoul, Korea), 14(3), 366–373.
  • Liampas, I., Siokas, V., Brotis, A., & Dardiotis, E. (2020). Vitamin D serum levels in patients with migraine: A meta-analysis. Revue neurologique, 176(7-8), 560–570.
  • Colombo, B., Saraceno, L. & Comi, G. Riboflavin and migraine: the bridge over troubled mitochondria. Neurol Sci 35, 141–144 (2014).
  • Yamanaka, G., Suzuki, S., Morishita, N., Takeshita, M., Kanou, K., Takamatsu, T., … Kawashima, H. (2021). Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients, 13(8), 2612.
  • Togha, M., Razeghi Jahromi, S., Ghorbani, Z., Martami, F. and Seifishahpar, M. (2019), Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache: The Journal of Head and Face Pain, 59: 1492-1503.
  • Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A Review of Its Effects on Human Health. Foods (Basel, Switzerland), 6(10), 92.


Concussions / TBI and Gut Disruptions

  • George, A. K., Behera, J., Homme, R. P., Tyagi, N., Tyagi, S. C., & Singh, M. (2021). Rebuilding microbiome for mitigating traumatic brain injury: Importance of restructuring the gut-microbiome-Brain Axis. Molecular Neurobiology.
  • Iftikhar, P. M., Anwar, A., Saleem, S., Nasir, S., & Inayat, A. (2020). Traumatic brain injury causing intestinal dysfunction: A review. Journal of Clinical Neuroscience, 79, 237-240.
  • Rice, M. W., Pandya, J. D., & Shear, D. A. (2019). Gut microbiota as a therapeutic target to ameliorate the biochemical, neuroanatomical, and behavioral effects of traumatic brain injuries. Frontiers in Neurology, 10.
  • Zhu, C., Grandhi, R., Patterson, T., & Nicholson, S. (2018). A review of traumatic brain injury and the gut microbiome: Insights into novel mechanisms of secondary brain injury and promising targets for Neuroprotection. Brain Sciences, 8(6), 113.


  • Laine, L. (2003). Gastrointestinal effects of NSAIDs and Coxibs. Journal of Pain and Symptom Management, 25(2), 32-40.
  • Maiden, L., Thjodleifsson, B., Seigal, A., Bjarnason, I. I., Scott, D., Birgisson, S., & Bjarnason, I. (2007). Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: A cross-sectional capsule Enteroscopy study. Clinical Gastroenterology and Hepatology, 5(9), 1040-1045.
  • Bouzari, A., Holstege, D., & Barrett, D. M. (2015). Vitamin retention in eight fruits and vegetables: a comparison of refrigerated and frozen storage. Journal of agricultural and food chemistry, 63(3), 957–962.

Published by Kelli Yates, RDN, LD, CLT

Kelli Yates, RDN, LD, CLT is a Registered Dietitian Nutritionist specializing in holistic migraine management and fellow migraineur!

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